Biological effects of grape stem extracts on human cancer cell lines

Grapes are rich in polyphenolic compounds, which known for their beneficial effects on human health. Grape stems byproducts of the winemaking procedure. They exert antioxidant effects; however, they can also become pollutants when discarded without control into environment due to high organic content. The main aim present study was examine potential prooxidant/anticancer grape stem extracts, promoting rationale scientific exploitation such compounds. Therefore, three extracts derived from native Greek vine varieties, Mavrodaphne, Muscat and Rhoditis were examined ability alter redox status [i.e., endogenous levels reduced glutathione reactive oxygen species (ROS)] HeLa HepG2 cancer cell lines. results revealed that exerted prooxidant tested lines, whereas extract Mavrodaphne did not any effects. fact functioned as prooxidants appears be detrimental cells, since more susceptible concentrations ROS, contrary healthy cells possess robust defense mechanisms. On whole, demonstrated study, it may prove promising agents against specific in vitro model. However, further studies required confirm these findings, vivo settings.